| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10916103 | Nuclear Medicine and Biology | 2011 | 8 Pages |
Abstract
The radiosynthesis of 123I-NKJ64 was achieved with good isolated radiochemical yield of 68% and a high specific activity of 1.8 Ci/μmol. TFA was found to be the most suitable deprotecting agent, since 2 M HCl generated a by-product that could not be fully separated from 123I-NKJ64 using the HPLC methodology investigated. This study highlights the importance of HPLC purification and accurate measurement of specific activity while developing new radiosynthesis methodologies.
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Authors
Adriana Alexandre S. Tavares, Nicola K. Jobson, Deborah Dewar, Andrew Sutherland, Sally L. Pimlott,