| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10916104 | Nuclear Medicine and Biology | 2011 | 8 Pages |
Abstract
In this research, two new fluorine-18 labeled 2-nitroimidazole derivatives, [18F]7 and [18F]8, both of which containing in vivo hydrolyzable group, were successfully prepared. Further biological evaluations are warranted to investigate their potential as PET radioligands for imaging tumor.
Keywords
T/BPTCTFAEtOAc18FTLCNAIDCMNa2CO3Et3NTHF[18F]FluoromisonidazoleRCYK2CO3DMF2-NitroimidazoleDMSOLC/MSN,N-dimethylformamideEthyl acetateSprague–DawleyTrifluoroacetic acidSPECTTetrahydrofurantriethylaminesingle photon emission computed tomographyPositron emission tomographyDichloromethaneDimethyl sulfoxideRadiochemical yieldHypoxiaPETPhase transfer catalystSodium carbonatePotassium Carbonatethin-layer chromatographySodium iodide
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Zhihao Zha, Lin Zhu, Yajing Liu, Fenghua Du, Hongmei Gan, Jinping Qiao, Hank F. Kung,