Article ID Journal Published Year Pages File Type
10916117 Nuclear Medicine and Biology 2011 6 Pages PDF
Abstract
Our results indicated that an improved transgene expression of 131I-stimulated hNIS in U87 cells using a baculovirus vector containing the Egr1 promoter is possible, and the increased expression of hNIS is responsible for a higher 131I uptake. It might provide a reference for the existence of a positive feedback effect in 131I-promoted Bac-Egr1-hNIS expression in malignant glioma and is an interesting aspect of NIS-related studies.
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