| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10916137 | Nuclear Medicine and Biology | 2012 | 9 Pages |
Abstract
Log P should not be relied upon as a predictor of blood-brain barrier penetration during brain radiotracer discovery. HPLC measurements of permeability, %PPB and membrane interactions may be potentially useful in predicting in vivo performance and hence allow evaluation and ranking of compound libraries for the selection of lead radiotracer candidates at early stages of radiotracer discovery.
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Authors
Adriana Alexandre S. Tavares, James Lewsey, Deborah Dewar, Sally L. Pimlott,