Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10916167 | Nuclear Medicine and Biology | 2005 | 6 Pages |
Abstract
We examined the densities of adenosine A2A receptors in cardiac and skeletal muscles between untrained and endurance-trained subjects using positron emission tomography (PET) and [7-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine ([11C]TMSX), a newly developed radioligand for mapping adenosine A2A receptors. Five untrained and five endurance-trained subjects participated in this study. The density of adenosine A2A receptors was evaluated as the distribution volume of [11C]TMSX in cardiac and triceps brachii muscles in the resting state using PET. The distribution volume of [11C]TMSX in the myocardium was significantly greater than in the triceps brachii muscle in both groups. Further, distribution volumes [11C]TMSX in the trained subjects were significantly grater than those in untrained subjects (myocardium, 3.6±0.3 vs. 3.1±0.4 ml gâ1; triceps brachii muscle, 1.7±0.3 vs. 1.2±0.2 ml gâ1, respectively). These results indicate that the densities of adenosine A2A receptors in the cardiac and skeletal muscles are greater in the endurance-trained men than in the untrained men.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Masaki Mizuno, Yuichi Kimura, Ken Tokizawa, Kenji Ishii, Keiichi Oda, Toru Sasaki, Yoshio Nakamura, Isao Muraoka, Kiichi Ishiwata,