Article ID Journal Published Year Pages File Type
10916354 Nuclear Medicine and Biology 2005 12 Pages PDF
Abstract
The reboxetine derivatives show a lot of promise as tracers for human PET studies of the norepinephrine system. We have identified a strategy for normalizing DVs to a reference region with the understanding that the DVR for these tracers may not be related to the binding potential in the same way as, for example, for the dopamine tracers, since the non-NET binding may differ between the target and nontarget regions. From our baboon studies the average DVR for thalamus (n=18) for SS-MRB is 1.8; however, the lower limit is most likely less than 1 due to this difference in non-NET binding.
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