Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10916354 | Nuclear Medicine and Biology | 2005 | 12 Pages |
Abstract
The reboxetine derivatives show a lot of promise as tracers for human PET studies of the norepinephrine system. We have identified a strategy for normalizing DVs to a reference region with the understanding that the DVR for these tracers may not be related to the binding potential in the same way as, for example, for the dopamine tracers, since the non-NET binding may differ between the target and nontarget regions. From our baboon studies the average DVR for thalamus (n=18) for SS-MRB is 1.8; however, the lower limit is most likely less than 1 due to this difference in non-NET binding.
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Authors
Jean Logan, Yu-Shin Ding, Kuo-Shyan Lin, Deborah Pareto, Joanna Fowler, Anat Biegon,