| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10916387 | Nuclear Medicine and Biology | 2005 | 7 Pages |
Abstract
123I-Iodo-α-methyltyrosine (IMT) transport into lymphomas has not been fully characterized. In rat Nb2-11C and Nb2-Sp lymphoma cell lines, linear uptake of 123I-IMT occurred rapidly within 5-10 min. Eadie-Hoftee plots of 123I-IMT uptake gave apparent Km's of 8.34±1.17 and 9.64±1.05 μM for Nb2-11C and Nb2-Sp cells, respectively, and involved the L and B0,+ systems. In lymphoma-bearing rats, injected 123I-IMT accumulated rapidly in the primary tumors but gave a low tumor-to-background ratio of 2:1. 123I-IMT was transported rapidly into lymphoma cells both in vitro and in vivo, but low target-to-nontarget ratio may not make 123I-IMT practical for scanning in vivo.
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Authors
Gilbert Matte, Shirley M. Sangster, Matthew Acker, Marlene Hudgins, Catherine K.L. Too,