| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10917920 | Radiotherapy and Oncology | 2015 | 7 Pages |
Abstract
We showed that nuclear EGFR selectively binds and stabilizes mRNA involved in the Warburg effect in response to irradiation. As a consequence, cells switch from aerobic to anaerobic glucose metabolism, which can be prevented by HIF1α inhibitor BAY87-2243, Dasatinib, Erlotinib or EGFR siRNA.
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Authors
Klaus Dittmann, Claus Mayer, Angela Paasch, Stephan Huber, Birgit Fehrenbacher, Martin Schaller, H. Peter Rodemann,