| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10918119 | Radiotherapy and Oncology | 2015 | 12 Pages |
Abstract
Trametinib radiosensitised RAS-/RAF-mutated melanoma cells by inducing prolonged G1 arrest and premature senescence. In this pre-clinical study we demonstrate that combining trametinib and RT is well tolerated, and reduces tumour growth in vivo.
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Authors
Ulrike Schick, Joan Kyula, Holly Barker, Radhika Patel, Shane Zaidi, Claire Gregory, Hind Hafsi, Victoria Roulstone, Eric Deutsch, Martin McLaughlin, Kevin Harrington,