| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10918544 | Radiotherapy and Oncology | 2014 | 7 Pages |
Abstract
The negative effect of [18F]FMISO HV on permanent local tumour control supports the prognostic value of the pre-treatment [18F]FMISO HV. Making the assumption that variable [18F]FMISO uptake in different FaDu tumours which all have the same genetic background may serve as an experimental model of intratumoural heterogeneity, the data support the concept of dose-escalation with inhomogeneous dose distribution based on pre-treatment [18F]FMISO uptake. This result needs to be confirmed in other tumour models and using fractionated radiotherapy schedules.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
![Effect of [18F]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice](/preview/png/10918544.png "First Page Preview: Effect of [18F]FMISO stratified dose-escalation on local control in FaDu hSCC in nude mice")
Authors
Christina Schütze, Ralf Bergmann, Kerstin Brüchner, Birgit Mosch, Ala Yaromina, Daniel Zips, Franziska Hessel, Mechthild Krause, Howard Thames, Jörg Kotzerke, Jörg Steinbach, Michael Baumann, Bettina Beuthien-Baumann,