Bone marrow transplantation rescues intestinal mucosa after whole body radiation via paracrine mechanisms

Article ID	Journal	Published Year	Pages	File Type
10918682	Radiotherapy and Oncology	2012	7 Pages	PDF

Abstract

Our result suggests BMT recruits host myelomonocytic cells and enhances intestinal stroma proliferation after radiation by secreting cytokines enhancing angiogenesis and chemotaxis. Host myelomonocytic cells further uplift the paracrine effect to enhance intestinal mucosal recovery.

Keywords

α-SMA Myelomonocytic cells PD-ECGF TIMP-4 DPP-4 FABP IP-10 PlGF WBI PDGF BMT GM-CSF SDF-1 IGF IL8 MMP EGF PBS bFGF Whole body irradiation α-smooth muscle actin Interleukin 8 Dipeptidyl peptidase-4 Intestine Cytokines epidermal growth factor placental growth factor Platelet-derived endothelial cell growth factor stromal cell-derived factor-1 Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)platelet-derived growth factor basic fibroblast growth factor Insulin-like growth factor granulocyte macrophage colony-stimulating factor Metalloproteinase Phosphate-buffered saline bone marrow Fatty acid binding protein Bone marrow transplantation