Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10918818 | Radiotherapy and Oncology | 2012 | 7 Pages |
Abstract
Signs and symptoms of severe late normal tissue complications present a very variable picture in the different organs at risk. Only in rare instances is the entire organ the critical target which elicits the particular complication. Moreover, the biological mechanisms that are involved in the pathogenesis differ between the different complications, even in the same organ. Different mechanisms are likely to be related to different shapes of dose effect relationships and different relationships between dose per fraction, dose rate, and overall treatment time and effects. There is good reason to conclude that each type of late complication after radiotherapy depends on its own specific mechanism which is triggered by the radiation exposure of particular structures or sub-volumes of (or related to) the respective organ at risk. Hence each complication will need the development of an NTCP model designed to accommodate this structure.
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Authors
Klaus-Rüdiger Trott, Wolfgang Doerr, Angelica Facoetti, John Hopewell, Johannes Langendijk, Peter van Luijk, Andrea Ottolenghi, Vere Smyth,