| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10919416 | Radiotherapy and Oncology | 2011 | 6 Pages |
Abstract
The correlation between expression of pEGFR and pAKT is indicative of activation of the PI3-K/AKT pathway through phosphorylation of EGFR. Since not all tumors show coexpression to the same extent, other factors must be involved in the activation of this pathway as well.
Keywords
PI3-KpEGFRHNSCCARCONpAktEGFRHIF-1αHead and neck cancerhypoxia-inducible factor-1αVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)phosphatase and tensin homolog deleted on chromosome 10phosphorylated AktHypoxiaPADPtenHead and neck squamous cell carcinomaEpidermal growth factor receptor
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Authors
Monique M. Nijkamp, Ilse J. Hoogsteen, Paul N. Span, Robert P. Takes, Jasper Lok, Paul F. Rijken, Albert J. van der Kogel, Johan Bussink, Johannes H.A.M. Kaanders,