Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10919422 | Radiotherapy and Oncology | 2011 | 8 Pages |
Abstract
Exposure to hypoxic conditions down-regulates UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia pathway. This pathway can potentially be exploited to target hypoxic cells in tumors.
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Authors
Chantal H.M.A. Ramaekers, Twan van den Beucken, Alice Meng, Shaqil Kassam, John Thoms, Robert G. Bristow, Bradly G. Wouters,