| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10919729 | Radiotherapy and Oncology | 2011 | 6 Pages |
Abstract
Nuclear EGFR is part of DNA-damage repair complex and is involved in regulation of TIP60-acetylase activity. TIP60 is essential for ATM activation and chromatin relaxation which is a prerequisite for DNA-repair in heterochromatic DNA. Thus interventional EGFR strategies during tumor treatment may also interact with DNA-repair by blocking access to damaged DNA.
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Authors
Klaus Dittmann, Claus Mayer, Birgit Fehrenbacher, Martin Schaller, Rainer Kehlbach, H. Peter Rodemann,