| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10919750 | Radiotherapy and Oncology | 2011 | 7 Pages |
Abstract
Our results demonstrate that hypoxia induced inhibition of translational control through regulation of eIF4E is an important mediator of hypoxia tolerance and radioresistance of tumours. These data also demonstrate that deregulation of metabolic pathways such as mTOR can influence the proliferation and survival of tumour cells experiencing metabolic stress in opposite ways of nutrient replete cells.
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Authors
Kasper M.A. Rouschop, Ludwig Dubois, Marco B.E. Schaaf, Twan van den Beucken, Natasja Lieuwes, Tom G.H. Keulers, Kim G.M. Savelkouls, Johan Bussink, Albert J. van der Kogel, Marianne Koritzinsky, Bradly G. Wouters,