| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10920137 | Radiotherapy and Oncology | 2005 | 9 Pages |
Abstract
The antagonistic effect of combined topotecan/irradiation treatment in fibroblasts was most likely due to an immediate radiation induced G1 arrest, but was not observed in p53 wildtype glioblastoma cells. Thus, the impact of TP53 on the topotecan response remains indistinct, and is obviously influenced by other genomic alterations acquired by tumor cells.
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Authors
Petra A. Ohneseit, Daniela Prager, Rainer Kehlbach, H. Peter Rodemann,