| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10920196 | Radiotherapy and Oncology | 2005 | 5 Pages |
Abstract
The dose-response for local tumor control after stereotactic radiotherapy of 92 pulmonary tumors (36 NSCLC and 56 metastases) was evaluated. Short course irradiation of 1-8 fractions with different fraction doses was used. After a median follow-up of 14 months (2-85 months) 11 local recurrences were observed with significant advantage for higher doses. When normalization to a biologically effective dose (BED) is used a dose of 94Â Gy at the isocenter and 50Â Gy at the PTV-margin are demonstrated to give 50% probability of tumor control (TCD50). Multivariate analysis revealed the dose at the PTV-margin as the only significant factor for local control.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Joern Wulf, Kurt Baier, Gerd Mueller, Michael P. Flentje,