Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10920369 | Radiotherapy and Oncology | 2005 | 10 Pages |
Abstract
The differences in radioresponse do not correlate with tumour oxygenation, suggesting that the hypoxic cells within the HIF-1 deficient tumours do not contribute to the outcome of radiotherapy. Thus, hypoxia impacts on tumour radioresponsiveness not simply because of the physio-chemical mechanism of oxygen with radiation-induced radicals causing damage 'fixation', but also because hypoxia/HIF-1 promotes expression of genes that allow tumour cells to survive under these adverse conditions. Further, the results from the cell mixing experiments uncouple the growth promoting effects of HIF-1 and the underlying mechanism by which HIF-1 may increase radiation resistance in solid tumours.
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Authors
Kaye J. Williams, Brian A. Telfer, Dia Xenaki, Mary R. Sheridan, Isabelle Desbaillets, Hans J.W. Peters, Davina Honess, Adrian L. Harris, Gabi U. Dachs, Albert van der Kogel, Ian J. Stratford,