| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926153 | Cell Calcium | 2015 | 7 Pages |
Abstract
- ER/PM microdomains are formed by tethering proteins such as the E-syts VAPs and the yeast homologues of Ist2.
- The ER/PM microdomains are divided to PI(4,5)P2-poor and PI(4,5)P2-rich domains.
- Dynamic translocation between the PI(4,5)P2-poor and PI(4,5)P2-rich domains is a new form of regulation of proteins in the ER/PM microdomains.
- Translocation of the Orai1-STIM1 complex from the PI(4,5)P2-poor to the PI(4,5)P2-rich domains determines STIM1 conformation and Orai1 gating by Ca2+.
Keywords
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Authors
Xu Cao, Seok Choi, Jozsef J. Maléth, Seonghee Park, Malini Ahuja, Shmuel Muallem,