| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926157 | Cell Calcium | 2015 | 11 Pages |
Abstract
- Assembly of STIM1 with Orai1 and TRPC within the ER-PM junctions lead to the gating and regulation of the channels.
- STIM2 and STIM1 tune channel activity to varying degrees of ER-Ca2+ store depletion.
- Integrity of ER-PM junctions are dependent on lipid as well as protein components.
- Dynamic remodeling of ER-PM junctions is critical for regulation of SOCE and Ca2+-dependent cell function.
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Authors
Hwei Ling Ong, Indu S. Ambudkar,