| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926174 | Cell Calcium | 2016 | 9 Pages |
Abstract
- Mice null for Tpcn2 in pancreatic β-cells were created using LoxP-mediated deletion.
- The absence of TPC2 had no impact on intraperitoneal or oral glucose tolerance.
- Glucose and GLP-1-induced Ca2+ dynamics were unaffected in null mouse islets.
- Functional redundancy of TPC channels appears to exist in β-cells.
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Authors
Matthew C. Cane, John Parrington, Patrik Rorsman, Antony Galione, Guy A. Rutter,