| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926191 | Cell Calcium | 2015 | 9 Pages |
Abstract
- Antibody against RyR1 reduced NAADP-evoked Ca2+ release by 81%.
- Combined inhibition of RyR1 and RyR3 (or RyR3-KO) reduced responses to NAADP by >90%.
- Knockout of TPC2 (or antibody against TPC2) reduced responses to NAADP by 64%.
- Combined inhibition of TPC2 and TPC1 reduced responses by 86%.
- In acidic stores inhibition of either pair of RyR1/3 or TPC1/2 abolished responses.
Keywords
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Authors
Julia V. Gerasimenko, Richard M. Charlesworth, Mark W. Sherwood, Pawel E. Ferdek, Katsuhiko Mikoshiba, John Parrington, Ole H. Petersen, Oleg V. Gerasimenko,