| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926192 | Cell Calcium | 2015 | 8 Pages |
Abstract
- Cardiac Ca sparks terminate when [Ca]SR falls to a certain critical level.
- Local [Ca]SR depletion terminates a spark by reducing the unitary RyR current.
- The reduced RyR current decreases [Ca] around a RyR cluster, thus breaking CICR.
- Multiple CICR termination mechanisms co-exist to ensure a stability of Ca cycling.
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Authors
Elisa Bovo, Stefan R. Mazurek, Michael Fill, Aleksey V. Zima,