| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926193 | Cell Calcium | 2015 | 10 Pages |
Abstract
- Fluoxetine suppresses the rise in [Ca2+]i after T cell receptor activation.
- The effect is due to depletion of intracellular Ca2+ stores.
- No effect of fluoxetine was observed on capacitative calcium entry.
- Fluoxetine inhibits Ca2+ release in response to inositol trisphosphate or caffeine.
- Inhibition of Ca2+ signaling is likely at the basis of fluoxetine-induced immunosuppression.
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Authors
V. Gobin, M. De Bock, B.J.G. Broeckx, M. Kiselinova, W. De Spiegelaere, L. Vandekerckhove, K. Van Steendam, L. Leybaert, D. Deforce,