| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926212 | Cell Calcium | 2015 | 10 Pages |
Abstract
- Type II pneumocytes containing lamellar bodies, secretory lysosomes, were studied.
- Ambroxol accumulates in lamellar bodies and disintegrates their ultrastructure.
- Ambroxol neutralizes the lamellar body pH.
- pH neutralization by Ambroxol or NH3/NH4+ releases Ca2+ from acidic stores.
- Ambroxol stimulates Ca2+-dependent exocytosis of lamellar bodies.
Keywords
EDXLELEXCLTGBCECFLROGPNIP3[Ca2+]cAmbroxolAutophagyLysosome-related organelleEnergy-Dispersive X-ray SpectroscopyinflammationEmissionBaf A1bafilomycin A1Alzheimer's diseaseLysosomal storage diseaseParkinson's diseaseNeurodegenerationHost defenseendoplasmic reticulumlamellar bodySecretory lysosomeMucusExcitation
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Authors
Giorgio Fois, Nina Hobi, Edward Felder, Andreas Ziegler, Pika Miklavc, Paul Walther, Peter Radermacher, Thomas Haller, Paul Dietl,