| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926216 | Cell Calcium | 2015 | 11 Pages |
Abstract
- ANO1 is a Ca2+-activated Clâ channel mediates numerous functions.
- Intracellular acid inhibits the Ca2+-activated ANO1 currents.
- Mutations at the Ca2+-binding site block the acid-induced inhibition.
- These results suggest that protons interfere with Ca2+.
- The acid-induced inhibition of ANO1 appears to be a feedback mechanism.
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Authors
Hyeyeon Chun, Hawon Cho, Jimi Choi, Jesun Lee, Sung Min Kim, Hyungsup Kim, Uhtaek Oh,