Article ID Journal Published Year Pages File Type
10926220 Cell Calcium 2015 13 Pages PDF
Abstract

- Downregulation of IP3R1 inhibits persistent Ca2+ oscillations in mouse eggs.
- Expression of wild type IP3R1 rescues ability to mount persistent Ca2+ oscillations.
- IP3R1s with phosphomimetic mutations show higher function and oscillations.
- Exogenous IP3R1s are resistant to downregulation, which enhance oscillations.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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