| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926224 | Cell Calcium | 2015 | 16 Pages |
Abstract
- UTP levels dramatically increase during myocardial ischemia and reperfusion.
- P2Y2, P2Y4 and P2Y11 differentially affect [Ca2+]i and growth of cardiac fibroblasts (CF).
- The P2Y4 receptor triggers fast [Ca2+]i rises and ATP release via Cx43-containing hemichannels.
- The adenylate cyclase/cyclic AMP/EPAC pathway mediates the P2Y11 receptor actions.
- The P2Y11 receptor counteracts the P2Y2-mediated pro-fibrotic effect of UTP.
- Anti-proliferative P2Y11 actions may afford protection against cardiac remodeling.
Keywords
CBXP2Y4 receptorPFAH-89IP3GPCRATPγSPLCUDPECMpKaKB-R7943cADPRSQ 225362-APBBFAEpacUTPMFQU73122cyclic adenosine diphosphate ribosePBSEGTA2-aminoethoxydiphenylborane9-(tetrahydro-2-furanyl)-9H-purin-6-amineN-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide dihydrochlorideCX43IBMXDDRRB-2DMEMFBS1-methyl-3-isobutylxanthine3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromidecyclic AMPBSADMSODulbecco's modified Eagle MediumG-protein-coupled receptorInositol 1,4,5-triphosphateMTTuridine 5′-diphosphate[Ca2+]iATPadenylate cyclaseATP releasebovine serum albuminEDTAEthylenediaminetetraacetic acidα-smooth muscle actinbrefeldin ASMAdimethylsulphoxidefetal bovine serumphospholipase Ccardiac fibroblastsExtracellular matrixmefloquineMyofibroblastparaformaldehydeExchange protein directly activated by cAMPprotein kinase AcarbenoxoloneIntracellular calciumconnexin 43P2Y2 receptorDiscoidin domain receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Mariana Certal, Adriana Vinhas, Ana Rita Pinheiro, Fátima Ferreirinha, Aurora Raquel Barros-Barbosa, Isabel Silva, Maria Adelina Costa, Paulo Correia-de-Sá,