Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10926226 | Cell Calcium | 2014 | 8 Pages |
Abstract
This brief review discusses recent advances in studies of mitochondrial Ca2+ signaling and considers how the relationships between mitochondria and Ca2+ responses are shaped in secretory epithelial cells. Perhaps the more precise title of this review could have been “How to win ATP and influence Ca2+ signaling in secretory epithelium with emphasis on exocrine secretory cells and specific focus on pancreatic acinar cells”. But “brevity is a virtue” and the authors hope that many of the mechanisms discussed are general and applicable to other tissues and cell types. Among these mechanisms are mitochondrial regulation of Ca2+ entry and the role of mitochondria in the formation of localized Ca2+ responses. The roles of Ca2+ signaling in the physiological adjustment of bioenergetics and in mitochondrial damage are also briefly discussed.
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Authors
Svetlana Voronina, Emmanuel Okeke, Tony Parker, Alexei Tepikin,