| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926235 | Cell Calcium | 2015 | 11 Pages |
Abstract
- Bile acids trigger Ca2+ release in pancreatic acinar cells.
- The Ca2+ release is attenuated by the RyR inhibitor dantrolene.
- Bile acid taurocholate (TCA) directly opens RyR type 1.
- TCA inhibits SERCA activity.
- TCA may contribute to Ca2+ overload in pancreatitis by activating RyR directly.
Keywords
CCHterminal cisternaeCa2+ induced Ca2+ releaseLongitudinal sarcoplasmic reticulumTLCSTaurodeoxycholateIP3RRyRFWHMTDCCPALSRTCA[Ca2+]iopen probabilityCyclopiazonic acidBile acidcalcium releasetaurocholateruthenium redendoplasmic reticulumintracellular Ca2+ concentrationSERCAPancreatitisPancreasCarbacholCICRInositol trisphosphate receptorRyanodine receptor
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Authors
Nikolett Geyer, Gyula Diszházi, László Csernoch, István Jóna, János Almássy,