| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926238 | Cell Calcium | 2015 | 12 Pages |
Abstract
- Cocaine enhances IP3-mediated Ca2+ signaling via sigma-1-receptor (Ï1R).
- This induces TRP canonical (TRPC) activation and depolarization of accumbal neurons.
- Intra-accumbal Ï1R/TRPC blockade reduces cocaine-hyperlocomotion/sensitization.
- We show behavioral relevance of a novel cocaine-triggered pathway in the accumbens.
Keywords
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Authors
Jeffrey L. Barr, Elena Deliu, G. Cristina Brailoiu, Pingwei Zhao, Guang Yan, Mary E. Abood, Ellen M. Unterwald, Eugen Brailoiu,