| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926245 | Cell Calcium | 2014 | 9 Pages |
Abstract
- S(+)MDMA (ecstasy) and 5HT (serotonin) induce Ca2+ mobilization in cultured muscle cells expressing hSERT.
- hSERT-mediated depolarization activates CaV1.3 but not CaV2.2 in HEK293 cells.
- The electrical coupling between hSERT and CaV1.3 takes place at physiological concentrations of 5HT.
- hSERT-mediated depolarization activates voltage-gated calcium channels.
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Authors
Iwona Ruchala, Vanessa Cabra, Ernesto Jr., Richard A. Glennon, Louis J. De Felice, Jose M. Eltit,