| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926263 | Cell Calcium | 2014 | 9 Pages |
Abstract
- The mitochondrial permeability transition pore (PTP) is a key effector in the pathways to cell death.
- The PTP forms from F-ATP synthase and is regulated by several signaling pathways.
- Tumor cells desensitize the PTP to Ca2+ and reactive oxygen species increasing their resistance to death.
- The PTP is a target for anticancer chemotherapeutics.
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Authors
Andrea Rasola, Paolo Bernardi,