Differential mechanisms of action of the mucolipin synthetic agonist, ML-SA1, on insect TRPML and mammalian TRPML1

- TRPML channels are important for lysosome trafficking and function.
- Studying Drosophila TRPML has revealed important information on TRPML function.
- ML-SA1 is a new agonist of mammalian TRPML channels.
- We found ML-SA1 only enhanced activity of open but not closed Drosophila TRPML.
- We found ML-SA to be a true agonist of mammalian TRPML1.