| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926268 | Cell Calcium | 2014 | 11 Pages |
Abstract
- DPB162-AE potently blocks functional coupling between STIM1 and Orai1.
- DPB162-AE specifically blocks Orai channel activation and not L-type or TRPC channels.
- SOAR-F394H binding to Orai1 is rapidly restored by DPB162-AE.
- Coupling of SOAR-F394H to activate Orai1 channels is slow.
- The site of action of DPB162-AE is at the STIM1-Orai1 coupling interface.
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Authors
Eunan Hendron, Xizhuo Wang, Yandong Zhou, Xiangyu Cai, Jun-Ichi Goto, Katsuhiko Mikoshiba, Yoshihiro Baba, Tomohiro Kurosaki, Youjun Wang, Donald L. Gill,