Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10926277 | Cell Calcium | 2012 | 8 Pages |
Abstract
Stimulation of mitochondrial oxidative metabolism by Ca2+ is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca2+ regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca2+-dependent regulation of ATP levels dynamically in single cells.
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Authors
Andrei I. Tarasov, Elinor J. Griffiths, Guy A. Rutter,