| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926309 | Cell Calcium | 2014 | 9 Pages |
Abstract
- ICRAC function depends on intra- and extracellular pH.
- Aspartic acids (D110/D112) in Orai1 contribute to the extracellular pH-dependence.
- Inhibition of Ca2+ influx by low extracellular pH is a general feature of ICRAC.
- Low pH in tumors and infection may thus contribute to dysfunctional Ca2+ signaling.
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Authors
Andreas Beck, Andrea Fleig, Reinhold Penner, Christine Peinelt,