| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10926361 | Cell Calcium | 2011 | 12 Pages |
Abstract
⺠We demonstrate functional GABA signaling in primary mouse lens epithelial cell cultures. ⺠Glutamic acid decarboxylase, GABA receptors, transporters and GABA are all abundantly expressed. ⺠GABAA and GABAB receptor agonists or GABA induce synergistic rise of intracellular Ca2+. ⺠Persistent activation of the GABAB receptors induces wave propagation of the Ca2+ wave and persistent oscillations. ⺠The GABA receptor mediated Ca2+ responses are sensitive to antagonists and extracellular Ca2+.
Keywords
CX43N-cadGABA-B receptorAAHN-cadherinLECVGCCGATGADDAPIGAD65P30Gad67VGAT4′,6-diamidino-2-phenylindoleE-cadE-cadherin[Ca2+]igamma-aminobutyric acidNeurotransmittersCell differentiationvesicular GABA transporterCNSpostnatal day 0central nervous systemLensintracellular Ca2+ concentrationIntracellular calciumconnexin 43GABAGABAARGABARGABABRGABA receptors
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Authors
Marija Schwirtlich, Andrea Kwakowsky, Zsuzsa Emri, Károly Antal, Zsombor Lacza, Attila Cselenyák, Zoya Katarova, Gábor Szabó,