The importance of Rho-associated kinase-induced Ca2+ sensitization as a component of electromechanical and pharmacomechanical coupling in rat ureteric smooth muscle

► RhoA/Rho-kinase in ureteric smooth muscle. ► ROK-catalyzed phosphorylation of MYPT1 at T855 is playing a key role in control of MLCP activity and LC20 phosphorylation in rat ureteric smooth muscle. ► Inhibition of ROK leads to an increase in the activity of MLCP, selective inhibition of tonic and acceleration of relaxation of phasic component of KCL- and CCh induced contracture.