Article ID Journal Published Year Pages File Type
10926547 Cell Calcium 2005 9 Pages PDF
Abstract
Dendritic spines are microstructures, about one femtoliter in volume, where excitatory synapses are made with incoming afferents, in most neurons of the vertebrate brain. The spine contains all the molecular constituents of the postsynaptic side of the synapse, as well as a contractile element that can cause its movement in space. It also contains calcium handling machineries to allow fast buffering of excess calcium that influx through voltage and NMDA gated channels. The spine is connected to the dendrite through a thin neck that serves as a variable barrier between the spine head and the parent dendrite. We review a novel modeling approach that is more suitable for the accurate description of the stochastic behavior of individual molecules in microstructures. Using this approach, we predict the calcium handling ability of the spine in complex situations associated with synaptic activity, spine motility and plasticity.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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