Article ID Journal Published Year Pages File Type
10926552 Cell Calcium 2005 5 Pages PDF
Abstract
Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their α1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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