Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10926971 | Cellular Immunology | 2015 | 21 Pages |
Abstract
Mesenchymal stromal cells (MSCs) possess a multi-lineage potential and immunoregulatory activities and provide a great potential in cell-based technologies. However, MSC suppressive activity raises concerns regarding the possible adverse effect of MSCs on the immune recovery. The influence of autologous MSC co-transplantation on recovery of T cell subsets in patients receiving autologous hematopoietic stem cell transplantation (AHSCT) for malignant lymphomas and multiple myeloma were characterized. Co-transplantation of MSCs improved lymphocyte recovery most effectively in patients with low input of hematopoietic stem cells or low absolute lymphocyte count in apheresis product. MSC co-transplantation improved early recovery of both memory and naive T cells with more prominent effect on naive CD4+ T cells. Patients with MSC co-transplantation showed more effective reconstitution of recent thymic emigrants. These data indicate the positive impact of MSCs on immune reconstitution and note MSC co-transplantation is feasible to optimize the outcomes of AHSCT in malignant lymphoma patients.
Keywords
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Authors
Egor V. Batorov, Ekaterina Ya. Shevela, Marina A. Tikhonova, Dariya S. Batorova, Galina Yu. Ushakova, Svetlana A. Sizikova, Vera V. Sergeevicheva, Andrey V. Gilevich, Irina V. Kryuchkova, Alexandr A. Ostanin, Elena R. Chernykh,