Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10927009 | Cellular Immunology | 2015 | 5 Pages |
Abstract
The most relevant results concerned the tendency to down regulation of CB HSPCs number with an increase of IL-4, IL-10 and GM-CSF levels, only the TNF concentration seems to have no influence on HSPCs pole size. The strongest positive correlations were found between CD34+CD45low HSPCs number and IL-10 and GM-CSF in MB serum and GM-CSF and TNF from CB supernatants. The strongest negative correlations were found between CD34+CD45low HSPCs number and IL-4 and GM-CSF in CB serum and IL-10 in MB supernatants. Interestingly, we observed 'opposite correlation' between serum and supernatant from CB and MB. We concluded that elevated serum levels of IL-4, IL-10 and GM-CSF in CB are indicative of enhanced differentiation of HSPCs and characterize a normal perinatal development. Elevated levels of cytokines seem to stimulate differentiation of HSPCs what is advantageous for neonates during perinatal period.
Keywords
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Authors
Magdalena SzaryÅska, Andrzej MyÅliwski, Jolanta MyÅliwska, Zbigniew KmieÄ, Krzysztof Preis, Piotr Zabul,