Article ID Journal Published Year Pages File Type
10927032 Cellular Immunology 2012 9 Pages PDF
Abstract

- Azithromycin, chloroquine and concanamycin impaire many lysosomal functions.
- Azithromycin and chloroquine deregulate TLR4 recycling, signaling and phospholipases.
- Stronger effect of concanamycin on lysosomes and TLR4 signaling.
- No effect of concanamycin on phospholipases and phospholipidosis.
- Impaired lysosomal functions - anti-inflammatory MOA of azithromycin and chloroquine.
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