| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10927036 | Cellular Immunology | 2012 | 7 Pages |
Abstract
- CHB is associated with impaired NK cell IFN-γ production in response to TLR9 stimulation.
- This impairment appears to be mediated through IFN-alpha mediated pathways.
- NK cells maintained the capacity for activation in response to TLR9 in CHB.
- The majority of the CHB associated changes involved the CD56dim subset of NK cells.
Keywords
FITCgranulocyte monocyte colony stimulating factorTNFchronic hepatitis B infectionCHBGM-CSFTLRFCSAPCALTPBMCPDCnatural killerAlanine aminotransferaseallophycocyanininterferonIFNinterferon-γinterleukintoll like receptorfetal calf serumPeripheral blood mononuclear cellPlasmacytoid dendritic cellNatural killer cellstumour necrosis factorphycoerythrinfluorescein isothiocyanateTRAILToll like receptorsHepatitis BHBVhepatitis B virus
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Authors
Dilip T. Ratnam, William Sievert, Kumar Visvanathan,