| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10927050 | Cellular Immunology | 2012 | 8 Pages |
Abstract
⺠We investigate the role of Trib3 in mouse bone marrow-derived mast cells (BMMCs). ⺠Trib3 expression is positively regulated by interleukin-3 (IL-3). ⺠BMMCs originating from Trib3-deficient mice display reduced viability when deprived of IL-3. ⺠Trib3 deletion impairs BMMC degranulation and cytokine mRNA induction in response to IgE-dependent activation.
Keywords
TRB3UPRGM-CSFDNPSCFBMMCsDAPIphorbol 12-myristate 13-acetateRT-qPCREPOATFreverse transcription-quantitative PCRIgETribTNF4′,6-diamidino-2-phenylindoleBSAC/EBPC/EBP homologous proteinPMAPCAbovine serum albuminPassive cutaneous anaphylaxiserythropoietinImmunoglobulin EinterleukinInterleukin 3Gene expressionCHOPDinitrophenylCell viabilityembryonic stemBone marrow-derived mast cellsendoplasmic reticulumgranulocyte-macrophage colony-stimulating factorStem Cell Factortumor necrosis factoractivating transcription factorMast cellknockout mousetribbles homolog 3Unfolded protein responseImmune responseCCAAT/enhancer binding protein
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Authors
Tiit Ãrd, Daima Ãrd, Sulev Kuuse, Mario Plaas, Tõnis Ãrd,