Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10927056 | Cellular Immunology | 2012 | 11 Pages |
Abstract
⺠Oral tolerance to OVA modifies the clinical course of CIA induced in BALB/c mice by administration of CII + OVA. ⺠Ingestion of OVA reduced serum levels of anti-CII antibodies and specific T cell proliferation. ⺠DCs from tolerant mice were able to suppress the immune responses of T lymphocytes from arthritic mice. ⺠Adoptive transfer of OVA-pulsed DCs mimic oral tolerance, suppressing the clinical signs of arthritis.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cell Biology
Authors
Rodolfo Thomé, Luis Gustavo Romani Fernandes, Marcela Franco Mineiro, Patricia Ucelli Simioni, Paulo Pinto Joazeiro, Wirla Maria da Silva Cunha Tamashiro,