Article ID Journal Published Year Pages File Type
10927072 Cellular Immunology 2012 6 Pages PDF
Abstract
► Sialidases reduce neurite and cell body density in microglia-neuron co-cultures. ► Siglec-F receptor is present on the surface of embryonic stem cells derived microglia. ► Enzymatic removal of sialic acids reduce affinity of Siglec-F to neuronal surface. ► Sialic acid-Siglec-F interactions protect neuronal integrity.
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Life Sciences Biochemistry, Genetics and Molecular Biology Cell Biology
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The participation of sialic acids in microglia-neuron interactions
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