HIF-1α signaling by airway epithelial cell K-α1-tubulin: Role in fibrosis and chronic rejection of human lung allografts

► Defines the role of Abs to Kα1T in patients with BOS following human lung transplantation. ► Demonstrate that Kα1T Abs signal through HIF-1α pathway leading to pro-fibrotic cascade. ► A direct role for immune response to a self-antigen plays a crucial role in chronic rejection.